SOD1 and Cerebral ischemia: A large number of ROS produced during cerebral ischemia excessivelyconsume the endogenous antioxidant enzymes, leading to the changes in the expressionand activity of various enzymes such as SOD, GSH-Px, CAT, etc.15The decreased activity of antioxidant enzymes reduces the ability of braintissue in scavenging ROS.