As an important partner of CLOCK, BMAL1 has been generally considered as a tumor suppressor in several types of cancer,46, 47 while several studies have suggest that BMAL1 has the potential to promote tumor growth and progression.37, 44 However, to date, no study has been focused on the biological roles of rs2279284 and rs1044432 in cancer. The gene discussed is CLOCK; the disease is neoplasm.