TP53 and non-small cell lung carcinoma: Moreover, we divide TP53 mutations into two types, disruptive and nondisruptive, based on the degree of disorder of p53 protein structure predicted from the crystal structure of the p53–DNA complexes.15 The results of our study demonstrated that nondisruptive TP53 mutations represent a heterogeneous subgroup of ALK‐rearranged NSCLC patients with inferior PFS.