HPN and B-cell chronic lymphocytic leukemia: For example, increased levels of hepsin, matriptase and TMPRSS2 have been found in prostate, breast, kidney and ovarian cancers.21, 22, 23, 24, 25 More recently, ectopic matriptase expression was reported in B‐cell lymphoma and chronic lymphocytic leukemia (CLL),26, 27 indicating that abnormal TTSP expression and/or activities may be involved in malignant hematological disorders.