For example, increased extracellular matrix degradation may create a tumor microenvironment that favors cancer cell growth.51, 52 Alternatively, the inhibitory effect of blocking HAT‐L4 expression on THP‐1 cell proliferation in the xenograft model was mediated by HAT‐L4 substrate(s) that were absent in our cell culture. The gene discussed is TMPRSS11D; the disease is neoplasm.