Severe ER stress induced cell death, invasion and alterations of morphology by decreasing the expression of unfolded protein response target genes, including CHOP, GRP78, and EF2a.14 ER stress induces epithelial‐mesenchymal transition in lung cancer cells and participates in the progression of metastasis.15, 16 In addition, ER stress‐induced invasion and migration of breast cancer cells can be suppressed by downregulation of heparanase.17 Our data demonstrated that silencing of NORAD can inhibit ER stress. The gene discussed is HPSE; the disease is breast cancer.