BCHE and early-onset autosomal dominant Alzheimer disease: Impairment of such processes may contribute to hippocampal failure in diseases such as Alzheimer’s disease, where loss of cholinergic neurons and Ca2+ dyshomeostasis have been described (Schliebs and Arendt, 2011; Magi et al., 2016; Berridge, 2014) and where cholinesterase inhibitors are the only class of drug that consistently improves memory in clinical trials (Birks et al., 2015; Birks, 2006).