Furthermore, H19 was hypothesized to additionally regulate expressions of EMT‐specific biomarkers (Figure 5), which also lowered sensitivity of cardiac cancer cells to chemotherapies.52 The EMT process robbed cells of their polarity and intercellular adhesion, which made for the occurrence of drug resistance.53 Besides, it was increasingly held that EMT was closely linked with the biological phenotype of tumor stem cells, which were verified as cell populations that were strongly resistant to drugs.54 The gene discussed is H19; the disease is neoplasm.