Several studies have suggested that stimulation of Ras‐Raf‐MEK‐ERK axis23, 24, 25 and Raf‐MEK‐ERK axis can result in glioma.26 In the present study, our results showed that the increased intracellular Ca2+ enhanced the expression of HPCAL1 followed by enhanced ERK activity. Here, MAPK1 is linked to central nervous system cancer.