Furthermore, VILIP1 also inhibits cancer progression via down‐regulation of α5 and αV integrins.9 Some studies have proved that the expression of HPCAL1 mainly occurred in the Purkinje cells of brain, and the protein HPCAL1 might participate in the regulation of neuron types.6 Studies have also indicated that reinforced expression of HPCAL1 stimulated ERK2 and its expression.10 It has been recognized that HPCAL1 is an innovative inhibitor of liver cancer, which was down‐regulated in the hepatocellular carcinoma (HCC) tissues and cells. The gene discussed is HPCAL1; the disease is cancer.