HPCAL1 and cancer: However, the expression of HPCAL1 has no correlation with the TMZ response in GBM cells, as both TMZ‐resistant cells (U‐118MG) and TMZ‐sensitive cells (U‐87MG and A172) have higher HPCAL1 expression.13 The expression of the gene HPCAL1 in 19 pairs of cancer tissues and the surrounding non‐cancer tissues was evaluated.