It has been demonstrated that the Wnt/β‐catenin axis participates in GBM28 The expression of β‐catenin was enhanced in several GBM cells, thus triggering Wnt target genes and promoting proliferation,29 invasion and migration.30 Findings of the present study suggest that HPCAL1 is an upstream effector of the Wnt/β‐catenin axis of GBM. Here, HPCAL1 is linked to glioblastoma.