Emerging reports indicate that Ca2+ could play a crucial part in positive regulation of initiation of GBM by affecting the maintenance, migration, quiescence and proliferation of malignant cells.5 As calcium pathway has been recognized to regulate diverse cellular reactions, it can be presumed that the pathway influences the progression of malignancy.19 Up‐regulation of HPCAL1 has been demonstrated in patients with GBM.12 In the present study, there was an up‐regulation of HPCAL1 in GBM cells, which enhanced proliferation of GBM cells worsening clinical outcome in participants with GBM. This evidence concerns the gene HPCAL1 and glioblastoma.