This apparent discrepancy could be because of the specific E‐cadherin antibody used.36 We observed a similar proportion of GH‐producing tumours displaying none or very low membranous E‐cadherin immunoreactivity compared to some studies17, 18 but a higher proportion compared to other studies.19, 23, 37 These discordant results could be related, at least partly, to differences in patients included in the studies. Here, CDH1 is linked to neoplasm.