Importantly, their results revealed that a significant association between E‐cadherin expression and response to SSAs could only be found when E‐cadherin accumulation was evaluated with the intracellular domain antibody.14 Therefore, the choice of antibody may severely influence the potential predictive value of E‐cadherin accumulation for the SSAs treatment response in acromegaly patients. This evidence concerns the gene CDH1 and acromegaly.