Molecular markers such as AIP, ZAC1 and RKIP and, prominently, somatotastin receptor subtypes (SSTRs) has been analysed in GH‐producing pituitary adenomas at the mRNA or protein level.7, 8, 9, 10, 11, 12, 13 Another molecular marker associated with SSAs response is the accumulation of E‐cadherin.14 E‐cadherin is a cell adhesion protein located at the cytoplasmic membrane and reported to work as a tumour suppressor. This evidence concerns the gene CDH1 and pituitary gland adenoma.