Univariate analysis showed that serum AFP level (more than 20 ng/mL) before resection, tumor diameter (more than 10 cm),with thrombus (portal vein), high Edmonson stage (stage 3‐4), high IDO expression, and intro‐tumoral neutrophils infiltration were prognostic factors for OS after resection (Table 1).Multivariate analysis showed high IDO expression (HR = 1.793, P = 0.028), intra‐tumoral neutrophils infiltration (HR = 2.159, P = 0.001), with thrombus (HR = 2.526, P = 0.000), and high Edmonson stage (HR = 1.848, P = 0.014) were independent prognostic factors for OS (Figure 2). This evidence concerns the gene IDO1 and neoplasm.