Furthermore, in case of vaccine failures, the antibody responses generally deviated from the responses in unvaccinated patients with TBE, with an early rise in IgG titers and neutralizing antibodies and late development and detection of IgM [18, 26], suggesting that cases of vaccine failures might have been overlooked and not properly diagnosed with TBE. The gene discussed is CD40LG; the disease is tick-borne encephalitis.