Nevertheless, new evidence suggest by in vivo and in vitro experiments that specifically lung cDC1, cDC2, and MoDCs are not infected by PRRSV-1 viruses from subtypes 1 and 3 and one possible explanation is the lower expression of CD163 and CD169 in those 3 DC subtypes, associating previous results of infection in DCs to culture conditions of monocytes in vitro that could cause a sensibilization to infection by certain strains as Lena (66). This evidence concerns the gene MPPE1 and infection.