RIPK3 and Hepatitis: Deleting either Ripk3 or Mlkl can suppress skin inflammation in RIPK1-deficient mice (Dannappel et al., 2014), and the fact that Ripk3 or Mlkl deficiency ameliorates liver inflammation and splenomegaly in Sharpin-deficient mice (Rickard et al., 2014a), suggesting that MLKL follows RIPK3 directly in necroptotic signaling, therefore confers a similar degree of protection against the abovementioned necroptotic-mediated injuries.