Nevertheless, there are also studies indicating that Mlkl deficiency confers less protection in the kidney IRI model compared to Ripk3 deficiency, and in contrast to Ripk3-deficient mice, Mlkl-deficient mice resemble wild-type mice in their sensitivity to hypothermia induced by low-dose TNF (Newton et al., 2016a). The gene discussed is RIPK3; the disease is medical procedure.