Some of the most notable examples included positive selection for Toll-like receptors, which encode for recognition of conserved sites of pathogens (Roach et al., 2005); Protein NLRC3, which modulate the activation of T-cells (Paria et al., 2016); E3 ubiquitin-protein ligase TRIM21, associated with anti-viral response (van der Aa et al., 2012); Lysozymes C and G, enzymes that can degrade bacterial cells walls during infection (Jiménez-Cantizano et al., 2008); and IL2 inducible T-Cell Kinase, which regulate the action of T-cells (Krasnov et al., 2013). Here, ITK is linked to infection.