Further, increases in several cytokines could trigger kidney injury in acute GVHD; when acute GVHD occurred, interleukin (IL)-2, IL-6, or tumor necrosis factor-α was upregulated in the kidney (Symington et al., 1992; Xun et al., 1995; Yang et al., 2017). The gene discussed is TNF; the disease is acute graft versus host disease.