Inhibitors targeting epidermal growth factor receptor (EGFR)-regulated pathways, Vascular endothelial growth factor (VEGF) pathway, multiple kinases, PI3-K/AKT/mTOR pathway, and other novel targets, in a combined modality treatment with immunotherapy, are likely to increase therapeutic efficacy in patients with HNSCC (Matta & Ralhan, 2009; Kaidar-Person, Gil & Billan, 2018). This evidence concerns the gene EGFR and head and neck squamous cell carcinoma.