SMAD4 and neoplasm: Some of the genes involved include VEGFA (angiogenesis) (Yue et al., 2012), WNT1 (proliferation), ERBB3 (proliferation) (Tang et al., 2016), SMAD4 (tumor suppressor) (Phuah et al., 2017), NDRG2 (radioresistance) (Wang W. et al., 2016) and EGFR (invasiveness) (Rupaimoole and Slack, 2017) all leading to tumor aggressiveness.