DICER1 and neoplasm: Similarly, Dicer has been shown to be downregulated through direct targeting of the DICER 3′ UTR by miRNAs such as miR-103/107 (Martello et al., 2010), let-7 (Tokumaru et al., 2008) and miR-630 (Rupaimoole et al., 2016) where tumor hypoxia further influenced these effects.