Although the role of lncRNAs in cancer progression and Lapatinib resistance have been reported in other studies (Russell et al., 2015; Li et al., 2016; Liang et al., 2018; Ma et al., 2018), this is the first study that proved that lncRNAs GIHCG and SPINT1-AS1 are involved in regulating therapeutic sensitivity to Lapatinib. Here, GIHCG is linked to cancer.