As shown in Figures 7F,G, suppression of GIHCG in Lapatinib resistant cancer cell lines NCIH-747 and BxPC3 could induce up-regulation of SPINT1-AS1 (P < 0.05), while knockdown of SPINT1-AS1 did not change the expression level of GIHCG (P > 0.05). This evidence concerns the gene GIHCG and cancer.