Findings from the RRA discovery study suggested that CD160 was the most significant gene aberrantly expressed in autoimmune diseases (Adjusted P = 5.9E-12), followed by CD58 (Adjusted P = 5.7E-06), CD244 (Adjusted P = 9.5E-05), LGALS9 (Adjusted P = 0.001) and CD27 (Adjusted P = 0.005) (Figure 1; Table 3). This evidence concerns the gene CD58 and autoimmune disease.