To investigate whether CD4+CD25−Foxp3+ T cells share phenotypic features resembling conventional CD4+CD25+Foxp3+ T cells in COPD patients, we analyzed the expression profiles of some classical markers relevant to Tregs, such as CD127, CTLA-4, HELIOS, TIGIT, and KI-67. This evidence concerns the gene IKZF2 and chronic obstructive pulmonary disease.