EZH2 and infection: On day 2 after infection, we validated the efficiency of Ezh2 deletion in Ezh2fl/fl SM-Cre cells (Supplementary Figure S3b) and observed a remarkable reduction in the TFH cell commitment of the Ezh2fl/fl SM-Cre cells compared to Ezh2+/+ SM-Cre cells (Fig. 3e, f).