For this purpose, on day 2 after infection, we divided SMARTA cells into three subsets, EZH2hi, EZH2inter and EZH2lo, according to their EZH2 expression levels and observed that the EZH2hi subset was much more poised to adopt the TFH fate than the EZH2inter and EZH2lo subsets (Fig. 2e, f), while the opposite phenotype was observed during TH1 differentiation (Fig. 2e–g). Here, EZH2 is linked to infection.