Acquisition of the mesenchymal phenotype by malignant cancer cells is associated with decreased cell–cell adhesion and increased migratory and invasive properties, which are crucial for metastasis.32 Our data show that ApoSQ- or ApoA-exposed CM prevented TGF-β1-induced cancer cell migration and invasion (Fig. 1f, g; Supplementary Fig. S6a and b), whereas control, NecSQ-exposed, and NecA-exposed CM did not. This evidence concerns the gene TGFB1 and cancer.