However, neither CM from nor direct exposure to epithelial cancer cells inhibited TGF-β1-induced EMT marker changes (Supplementary Fig. S4a–d), indicating that cancer cell EMT inhibition requires bioactive mediators that are secreted by professional phagocytes, such as macrophages, which are functionally altered by apoptotic cancer cell stimulation. This evidence concerns the gene TGFB1 and cancer.