It was shown previously that DNA methylation alterations at the IGF2/H19 imprinted domain may mediate the association between HPV and invasive cervical cancer48 and high H19 expression has also been shown to be predictive of poor prognosis in cervical cancer49 as well as in a variety of other human cancers, including HNSCC50 and breast cancer51. Here, IGF2 is linked to cancer.