Correspondingly, in the pMMR CRC cell lines SW480 and FET, the IC50 to FU and cell viability under FU challenge were significantly decreased in ABHD5 knockdown cells (Fig. 1b, c, Supplementary Fig. 1a) and substantially increased in ABHD5 overexpression cells (Supplementary Fig. 1b) relative to control cells. Here, ABHD5 is linked to colorectal carcinoma.