To assess the therapeutic potential of our inhibitor in an experimental setting that more closely resembles clinical situations and in females (the above described calcium phosphate model was conducted in young male mice), we next induced aortic aneurysm formation with Angiotensin II (Ang II) infusion in 9-month-old apolipoprotein E–deficient (Apoe−/−) female mice. The gene discussed is APOE; the disease is aortic aneurysm.