PCSK1 and aortic aneurysm: Based on the formerly described dose response study in which GSK’074 inhibited SMC necroptosis with an IC50 that was ~0.3% of that of Nec-1 s, we selected 0.93 mg/kg/day (2 μmol/kg/day) to test this new class of inhibitors in mouse models of aortic aneurysm.