SHBG and Thromboembolism: Table 2 shows that testosterone predicted by 21 genetic variants from the SHBG gene region using principal components analysis was not associated with thromboembolism (odds ratio 1.08, 95% confidence interval 0.83 to 1.42), heart failure (1.78, 0.82 to 3.87), or myocardial infarction (0.79, 0.59 to 1.04).