Supplementary table 5 shows that, with inverse variance weighting, sex hormone binding globulin predicted by seven genetic variants from the SHBG gene region was positively associated with thromboembolism overall (1.35, 1.02 to 1.79); however, it was inversely associated with myocardial infarction in men (0.69, 0.49 to 0.97) and was not associated with heart failure in the UK Biobank (1.42, 0.64 to 3.16). Here, SHBG is linked to heart failure.