PKD2 and Familial prostate cancer: We have previously demonstrated that PKD2 or PKD3 did not promote angiogenic factor VEGF expression in prostate cancer cells [35], which is confirmed by the ELISA results that depletion of PKD2 or PKD3 has no effect on VEGF secretion in either prostate cancer cells (Additional file 6: Figure S4A-B) or mast cells (Additional file 6: Figure S4C-D).