To provide insights into the effect of PKD2/PKD3 on the recruitment of MCs, tumor angiogenesis and tumor growth in prostate cancer model, mouse prostate cancer RM1 cells were injected subcutaneously into C57BL/6 mice, mice with RM1 tumors were randomized to three groups as described in method (Fig. 6a). This evidence concerns the gene PKD2 and Familial prostate cancer.