CCL5 and Familial prostate cancer: In prostate cancer cells with overexpressed with PKD2 and PKD3 (Fig. 4e), ELISA and RT-qPCR assay demonstrated that Erk specific inhibitor PD98059 (PD) antagonized the upregulation of SCF (Fig. 4f) and CCL5 expression (Fig. 4g) induced by PKD2 or PKD3 in DU145 cells.