In this study, we have demonstrated that knockdown of PKD2/3 or inhibition of PKD activity in prostate cancer cells in vitro significantly repressed MCs recruitment through regulating AP-1 or NF-κB mediated transcription of SCF, CCL5 and CCL11, thereby inhibiting angiogenic factors expression in MCs. This evidence concerns the gene NFKB1 and Familial prostate cancer.