In prostate cancer cells with overexpressed with PKD2 and PKD3 (Fig. 4e), ELISA and RT-qPCR assay demonstrated that Erk specific inhibitor PD98059 (PD) antagonized the upregulation of SCF (Fig. 4f) and CCL5 expression (Fig. 4g) induced by PKD2 or PKD3 in DU145 cells. The gene discussed is PKD2; the disease is Familial prostate cancer.