E2F4 and pulmonary fibrosis: It was found that (1) mMSCs overexpressing p130 or E2F4 further attenuated pathological damage in ARDS mice after transplantation; (2) mMSCs overexpressing p130 or E2F4 further attenuated the injuries of AT II in ARDS mice, further improving not only the structure but also their functions; (3) mMSCs overexpressing p130 or E2F4 further increased the retention of MSCs in ARDS mice after transplantation; and (4) mMSCs overexpressing p130 or E2F4 decreased pulmonary fibrosis in ARDS mice.