The most remarkable results have been achieved with brentuximab vedotin (BV), an antibody drug conjugate directed against CD30, which has indeed shown good tolerance as well as promising activity in CD30+ lymphomas, with an overall response rate (ORR) of 75% and complete response (CR) rate of 34% in patients with relapsed or refractory HL [16] and an ORR of 86% and CR rate of 57% in relapsed or refractory systemic ALCL [17]. This evidence concerns the gene TNFRSF8 and lymphoma.