In most patients treated, CAR transgene levels in the peripheral blood peaked at 3–9 days after infusion and decreased to baseline at 4–8 weeks after infusion Higher numbers of CAR transgenes as well as a decreased number of CD30+ tumor cells were found in the few patients who had tumor biopsies performed at that time, suggesting that functional CAR-T cells trafficked to tumor sites. The gene discussed is TNFRSF8; the disease is neoplasm.