When serum level of MIF was increased by 1 ng/ml, the unadjusted risk for disseminated TB would be increased by 8% (OR: 1.08 [95% CI: 1.03–1.14], P = 0.005); and the adjusted (including age, cavitary lesion, pleural effusion, drug-resistant, ALB, CRP, WBC and IL-6) risk would be elevated by 3% (OR: 1.03 [95% CI: 1.00–1.10], P = 0.016). This evidence concerns the gene CRP and tuberculosis.