Therefore, with QSG-7701 hepatocytes co-cultured in pairs with lung cancer cells (A549, LTEP-α-2 or NCI-H1703) or normal HBE cells, we evaluated the effects of lung cancer tissue-derived secretory products on hepatocyte complement synthesis and secretion by comparing the expression differences of 10 complement components (C3, C4, C5, C4BPA, C4BPB, C6, C7, C9, CFH and CFI) in QSG-7701 hepatocytes co-cultured in pairs with lung cancer or normal cells. This evidence concerns the gene C5 and lung cancer.