LRRK2 and Parkinson disease: Although deleterious mutations in α-synuclein (OMIM-163890) [47], leucine-rich repeat kinase 2 (OMIM-609007) [48], vesicular protein sorting 35 (OMIM-601501) [49], parkin (OMIM-602544) [50], PTEN induced putative kinase 1 (OMIM-608309) [51], and DJ-1 (OMIM-602533) [52] have been found in multi-incident families with parkinsonism, mutations in the translation initiator, eukaryotic translation initiation factor 4 gamma 1 (eIF4G1, UniProt: Q04637), have also been reported [53].