AGT and Marfan syndrome: Interestingly, RES was beneficial against aortopathy in four different aortic aneurysm models; namely in the local periaortic application of calcium chloride (CaCl2)-model, in the local inter-aortic elastase infusion model, in the systemic chronic infusion of angiotensin-II (AngII) model and in the genetic FBN1-mutation (Fbn1C1039G/+) model of MFS [8,11,12,13].