EGFR and malignant colon neoplasm: In H508 human colon cancer cells, bile acids increased cell proliferation, an effect blocked by atropine (a non-selective muscarinic receptor antagonist) and inhibitors of epidermal growth factor receptors (EGFR), confirming that proliferative effects are mediated by interplay between two very different classes of receptors, G protein-coupled receptors and receptor tyrosine kinases [38].