Our exploratory analyses found interactions between polymorphisms in the fatty acid metabolic pathway (LPCAT1 s7737692 and SLC25A20 rs7623023) and polymorphisms that have been found to interact with NSAID/aspirin (CCAT2 rs6983267 and TP53 rs1042522) on one hand and intake of red and processed meat on the other in relation to risk of CRC. This evidence concerns the gene TP53 and colorectal carcinoma.