Table 1 shows the baseline characteristics of 1038 CRC cases and 1857 sub-cohort members including CRC risk factors. Among the controls, the genotype distributions of the studied polymorphisms were in Hardy–Weinberg equilibrium. In order to maximize the statistical power for the interactions analyses, the genotypes were combined assuming either a dominant model (SLC25A20 rs7623023, TP53 rs1042522, CCAT2 rs6983267, BCL2 rs2279115) or a recessive model (PRKAB1 rs4213, LPCAT1 rs7737692, PLA2G4A rs4402086, ALOX5 rs3780894, PTGER3 rs6685546, TCF7L2 rs7903146) based on the observed risk estimates. The gene discussed is BCL2; the disease is colorectal carcinoma.