The basic mechanisms underlying migration of GBM cells are equivalent to those present in most types of migratory cells; to the point that, as migration is a property of many non-tumor cells, although restricted to specific developmental stages or environmental conditions, the migration of tumor cells is often viewed as the result of dysregulation of specific biochemical pathways as, for example, PI3K/Akt/mTor [14,15] that in non-pathological conditions tightly control the migration of cells. The gene discussed is AKT1; the disease is glioblastoma.