GPT and Decreased total leukocyte count: The most common treatment-related AEs were in line with the previously mentioned trial: AST elevation (all grades: 50%, grade ≥ 3: 3%), ALT elevation (all grades: 43%, grade ≥ 3: 3%), leukopenia (all grades: 33%, grade ≥ 3: 7%), neutropenia (all grades: 33%, grade ≥ 3: 10%) and numbness (all grades: 23%, grade ≥ 3: 0%).