According to our data from nintedanib-treated IPF fibroblasts and the literatures, we proposed that upregulation of hsa-miR-486-3p following nintedanib treatment might be associated with decreased expression of DDX11, E2F1, and PLXNA4. These gene expression changes together might contribute to decreased proliferation of fibroblasts and decreased angiogenesis in the microenvironment of IPF (Figure 8). This evidence concerns the gene E2F1 and idiopathic pulmonary fibrosis.