RB1 and neoplasm: Although HPV alone is not sufficient to induce malignant transformation of cervical epithelial cells, expression of HPV oncoproteins E6 and E7 leads to inactivation of critical tumor suppressors such as TP53 and RB1 in many types of cells (Dyson et al., 1989; Scheffner et al., 1990; White et al., 2016).