Both in vitro and in vivo evidence indicates that dysregulation of the Hippo signaling cascade and activation of proto-oncogene YAP1 are linked to many human cancers, including cancers of the skin, lung, colon, breast, kidney, liver, and ovary (Gomez et al., 2014; He et al., 2015a; Lee et al., 2010; Steinhardt et al., 2008). The gene discussed is YAP1; the disease is cancer.