As expected, expression of genes encoding ISGs that directly inhibit virus infection, such as MX1 (myxovirus resistance 1), ISG15, APOBEC3G (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G), OAS1 (2′-5′-oligoadeny-late synthetase 1), TRIM5 (tripartite motif family protein 5), and IFI44L, was significantly downregulated in YAPS127A-expressed hCerECs (Figures 5A and S9A). This evidence concerns the gene ISG15 and viral infectious disease.