Importantly, CSF from tauopathies, such as supranuclear palsy, did not seed α‐synuclein aggregation in either assay.14, 15 Of note, there are rare cases of PD that lack LB pathology, including the R1441 and G2019S LRRK2 mutations, in which the role of synucleinopathy in disease pathogenesis is questioned.26, 27, 31 There were 2 cases of G2019S LRRK2 mutation in the present BioFIND cohort: 1 PD and HC subject. The gene discussed is LRRK2; the disease is synucleinopathy.