It is also known that diet-induced obesity can reduce the expression of HSPs, while the increase of HSP expression can prevent or reduce the damage caused by obesity, promoting an improvement in insulin sensitivity, glucose tolerance, inflammation reduction and an increase in insulin signalling (Henstridge et al. 2014, Chung et al. 2008, Gupte et al. 2009; Moura et al. 2018). Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.