AKT1 and metabolic dysfunction-associated steatotic liver disease: Angelini et al. 2018 presented a study where a high-energy, high-carbohydrate and high-fat diet can trigger hypersecretion of heat shock proteins from the small intestine that can lead to insulin resistance through inhibition of Akt phosphorylation, insulin-mediated GLUT translocation on the cell membrane and ectopic intracellular fat accumulation with NAFLD development.