Numerous studies have suggested that insulin, rather than blood glucose, is an independent risk factor for pancreatic cancer.16, 17 Indeed, insulin can promote pancreatic cancer cell viability and cancer progression.19, 26 Therefore, this study explored the role of physiological concentration of insulin in the malignant progression of human pancreatic duct‐derived cells, as well as clarifying the underlying mechanism in vitro. The gene discussed is INS; the disease is familial pancreatic carcinoma.