INS and type 2 diabetes mellitus: In addition, studies in genetically engineered mouse models have also shown that oncogenic KRAS can induce mPanIN spontaneously14 and that type 2 diabetes caused by a high‐fat, high‐calorie diet can accelerate the development of precancerous lesions.15 Numerous studies have investigated how insulin, rather than blood glucose, is an independent risk factor for pancreatic cancer.16, 17 However, the direct contribution of hyperinsulinemia to the increased incidence of pancreatic cancer in type 2 diabetes remains unclear.