The results of this study show that the majority of ACC express IGF2, IGF1R and IGF2R mRNA and protein and demonstrate IRA mRNA expression in these tumors, suggesting that factors such as IGF2R and IRA, not well described before, could interact with IGF2, potentially modulating the role of IGF2 in adrenocortical tumorigenesis. Here, IGF2 is linked to adrenal cortex carcinoma.