Our assessment of enzyme expressions and the FA carbon chain length of CERs in this cytokine environment, in combination with our previous findings in cultured keratinocytes [23], strongly suggests that IFN-γ may be involved in the decrease of CERs with long-chain FAs in the epidermis through the reduction in ELOVL expression in FAg-induced AD-like dermatitis. The gene discussed is IFNG; the disease is skin disorder.