Six hours after the last application of FAg, mRNA expression of IFN-γ increased by 163-fold in the AD-like dermatitis as compared with that in control mouse skin, and the expression of TNF-α, IL-12/IL-23, IL-17, and IL-22 also increased (Figure 1 and Supplemental Table 2a). The gene discussed is IL22; the disease is Alzheimer disease.