MXD3 and acute lymphoblastic leukemia: Furthermore, MXD3 has been shown to be upregulated in proliferating cerebellar granule neuron precursors (GNPs), in cerebellar tumors derived from the patched heterozygous mouse model of medulloblastoma (Yun et al., 2007), in human medulloblastoma (Barisone et al., 2012), and in human acute lymphoblastic leukemia (ALL) (Barisone et al., 2015).