When the frequency of the PPARG rs3856806 CC/CT genotype was used as a reference, individuals carrying the PPARG rs3856806 TT genotype had a significantly increased susceptibility to CRC (crude OR = 1.62, 95% CI 1.11–2.37 for TT vs. CC/CT, P = 0.012). This evidence concerns the gene PPARG and colorectal carcinoma.