PPARGC1A and obesity due to melanocortin 4 receptor deficiency: As CRC is associated with obesity and Waist-to-Hip Ratio (WHR) (8–10), the peroxisome proliferator-activated receptor gamma (PPARG), PPARG co-activator 1 (PPARGC1) family (e.g., PPARGC1A and PPARGC1B) may be strong candidate genes predisposing to CRC (11).