ABCC11 and adenocarcinoma: Among other mechanisms involved in pemetrexed resistance, Uemura et al. demonstrated that ATP-binding cassette-transporter 11 (ABCC11) may represent a biomarker for pemetrexed treatment in adenocarcinomas and that a single-nucleotide polymorphism in the ABCC11 gene constitutes an important determinant of pemetrexed sensitivity [8].