A time- and dose-dependent reduction of ErbB2 expression was observed in these cervical cancer cells, whereas the underlying mechanism of aspirin's antiapoptotic effects was due to its inhibition on the activation of extracellular signal-regulated kinase (ERK) and AKT (also known as protein kinase B), as well as the inhibition of Bcl-2 expression [62]. This evidence concerns the gene AKT1 and cervical cancer.