To identify alternative genetic events that can potentially explain the elevated YAP/TAZ activity exhibited in some human breast cancers, we applied CaDrA using genomic data from the TCGA BRCA sample cohort, along with corresponding per-sample estimates of YAP/TAZ activity derived using a gene expression signature of YAP/TAZ knockdown in MDA-MB-231 cells (see section “Methods”). This evidence concerns the gene WWTR1 and breast carcinoma.