To demonstrate CaDrA’s targeted search mode when identifying genomic alterations that track with a pre-defined starting feature, we ran CaDrA using phosphorylated EGFR (EGFRTyr1068) protein expression levels to stratify TCGA lung adenocarcinomas (LUAD), and seeded the search process with EGFR mutations. This evidence concerns the gene EGFR and lung adenocarcinoma.