NTRK1 and neoplasm: In the first iteration, CaDrA identified the top scoring genomic feature to be a deletion on chromosomal locus chr5q21.3 (Figure 5A), harboring tyrosine kinase receptor-encoding gene EFNA5. EFNA5, a member of the Eph receptor family, has been hypothesized to function as a tumor suppressor, whose expression has been shown to be reduced in human BRCAs relative to normal epithelial tissue (Fu et al., 2010).