The expression of P311 was also found in small-cell lung carcinoma (SCLC), large-cell neuroendocrine carcinoma (LCNEC) (Jones et al., 2004) and glioblastoma (Mariani et al., 2001), whose cells had a really high proliferation capability, which indirectly implied that P311 might regulate the proliferation of cells. This evidence concerns the gene NREP and large cell neuroendocrine carcinoma.